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Old 07-03-2020, 06:15 AM
Charles Charles is online now
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Before proposing a theoretical solution to mutation, let's discuss the bacterial cell. It is a remarkable device or object. It has created the most dense digital storage medium (DNA) by far in existence and harnesses the second law to create mutations so that it can survive. Not only does this little creature harness the second law, in my humble opinion, it transcends the second law. Let me explain.

In the 1920's a physicist named Leo Szilard proved that digital information like DNA ought to obey the second law of thermodynamics. This should mean that as bacteria mutate their genomes should gradually degenerate. Thus, the end of bacteria. Well, tell that to a bacteria or a virus. Both thrive on mutation and need mutation to survive.

The other remarkable thing about bacteria is their development of an elegant digital code (the Universal DNA Code) and a digital molecule (DNA) from the very beginning of their existence. Now one would naturally expect the little buggers to develop biological digital networks to procreate (multiply) and create their proteins. You got an incredible digital storage medium, an incredible code, and the coding of this digital storage medium because DNA is a coded molecule. (DNA codes for proteins. Proteins are the building blocks of Life.) The little buggers also developed a means of expressing this digital information (the transfer RNA's and ribosomes) but incredibly, employ random chance not only to create new digital information but also to decode all their digital information in the form of transcription and translation. Thus creating substantial error in all their proteins. Bacteria "forgot" to develop the digital networks which could ensure 100% perfect replication, transcription, and translation. And thus the elimination of all error caused by the second law inside their little bodies. But did they really forget?

Because viral and bacterial genomes remain extremely robust and show no evidence of the deleterious effects caused by the second law on their genomes. In fact their genomes employ the second law to survive. Szilard says to them, "You must die". They say back, "We choose to live."

Humans should be so fortunate as I will explain below.

Last edited by Charles; 07-03-2020 at 06:26 AM.
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  #22  
Old 07-03-2020, 09:30 AM
cleeds cleeds is offline
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Originally Posted by Charles View Post
... I am a great believer in holistic medicine. To me it's all about diet and exercise. I take no meds, weigh 140 lbs, and walk about 50-60 miles per week. I have a home gym. When ever I get tired I think: cancer, diabetes, high blood pressure, stroke, and heart attack. This motivates me to keep going.

Medical science doesn't care about cures. It wants to treat. It would be devastating if disease was cured.
This is so very true although many people - including medical professionals - simply can't accept it.

For example, we've proven that heart disease is reversible. But of course there's much more profit in surgical and pharmaceutical interventions.
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Old 07-03-2020, 12:49 PM
Charles Charles is online now
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This is so very true although many people - including medical professionals - simply can't accept it.

For example, we've proven that heart disease is reversible. But of course there's much more profit in surgical and pharmaceutical interventions.
Cleeds, I appreciate your comments. I went to the dermatologist for my yearly skin check. He's a good friend of mine. We catch up on the news about our comrades in arms. A few months ago my personal physician and a good friend died of heart complications. He was much younger than me. Two days ago I learned of the death of a prominent physician and friend of mine from prostate cancer. He was probably 10 years younger than me. I was shocked.

Almost no one knows about my research. Why would they? I'm a superb clinician but not a basic science researcher. But biochemistry, DNA, the human genome and its organization have been hobbies of mine for 40 years. I've never published anything. I find biochemistry endlessly fascinating but as I have advanced in age, I do less and less reading.

Here's a few more comments/thoughts. I did not come to these thoughts overnight. They are the result of many years of study:

p.s. I left out mRNA. Messenger RNA is the copy of the gene that sets on the ribosome for translation. So you have the hard drive, i.e. the chromosome, the coded DNA, mRNA, tRNA, and ribosome, all digital molecules, but no digital networks. Digital networks really amount to an active process that supplies the enzyme with the correct base or amino acid, rather than relying on the passive process of diffusion. Relying on diffusion amounts to using the second law to supply the digital information to these elegant incredible molecular structures/machines. Just the enzymes are incredible molecular machines. The fact that they are capable of extremely accurately asking and answering the huge number of yes/no questions necessary for any cell to function, i.e. procreate and produce its proteins is remarkable. However, an active process would supply the enzyme in question with the correct piece of digital information 100% of the time. Suppose the enzyme made a mistake in a system with an active process. No problem. The active process would simply proceed to supply the enzyme again with the necessary/correct nucleotide or tRNA to correctly make the bond.

Suppose the active process was temporarily interrupted. No problem. The enzymes themselves can operate very accurately without it for an extended length of time with very low probability of significant error.

Below I will propose some elegant solutions and equations that theoretically eliminate the the built-in error created by the second law, i.e. diffusion. These solutions and equations amount to an active process as opposed to the passive process of diffusion. If these active processes were incorporated into human cells, disease as we know it would be eliminated. This is original work, my work.

Best

Charles

Last edited by Charles; 07-03-2020 at 01:39 PM.
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