There are so many watches I desire but if I had to pick one, it'd be the Lange Zeitwerk Striking Time.
It was love at first sight with this watch but at close to 100k€ this will remain a dream.
Slightly less expensive, you have the perpetual calendar 5140 by Patek
So cheap, it's almost free at 45k€
the Vacheron double retrograde
The most outside of the box thinking, the HYT H1 with liquid system
The one I hope will be my next one. The Jaeger Lecoultre Master Ultra Thin Perpetual Calendar. The most "affordable" perpetual calendar even Patek salesmen are amazed.