Expanding on the thought of the SIM characters... Even if they work out their beginning to the moment of the BIG BANG as their world came to be... (the moment the computer/device was turned on and program started running) They will never be able to resolve any further.
They will never know who plugged the computer in or who designed the program to begin with, not that they would be able to jump the barrier of knowledge between the first spark and the higher power responsible for all the other necessary events leading up to that moment.
I say this with from a completely agnostic point of view and having nothing to do with religion. Although of course science and religion may very well run parallel to each other without realizing exactly how much that can be so...
