I just remembered one thing that happened on MY MS300 a couple years back. Also would not boot so put new drive in, installed software and all ok. Kept the old drive anyway and tried it again some time later and it was fine. Turned out to be the ribbon data cable was faulty, so try unplugging and plugging that back in also, both ends of it in fact or replacing as they are cheap. If you do replace the drive, we have also found that even new (so called, but probably re-firbed) drives that are the correct spec do not all work for some reason. Frustrating......
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