Driving ref250s today. And as one might expect, consider it a great pairing. I've never used the electronics to drive Vandersteens.
I've heard the 5se and ref150 driving both the Quatros and 5a. Both sounded good, but the 5A were a big step up. The 5a listening included some large orchestra passages, and I didn't find the Vandersteens were wanting for power.
There is probably a reason you choose a tube pre. I'd defiantly give the 150 a listen before pulling a trigger on the 450.
Best!
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