I have never owned or heard a VK-50SE or VK-51SE, but I can tell you that the VK-53SE bettered the VK-52SE in my own experience, and it is a fairly safe bet that the VK-52SE was an improvement over the VK-50SE. Therefore, I would expect the VK-53SE to be a substantial step up from the VK-50SE. The areas of improvement I heard between the VK-52SE and Vk-53SE were primarily in dynamics, then size of the sound stage, localization of instruments in that sound stage, detail or resolution, and bass and treble extension.
I do not believe that there is a direct upgrade path from the VK-50SE to VK-53SE.
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