I have run Blue Jean cable 10 ga to my Bryston Mini-T speaker locations (in wall) and they sound good, don't get me wrong. I've spent several hours getting the best speaker layout I can, following the Sumiko speaker placement guide. The presentation, and over all soundstage with Jennifer Warnes is beautiful.
However, I was playing with the speakers wired directly to the amp, horrible speaker placement by the way, in a Bi-Amp configuration using the AQ Rocket 88 cables for the tweeters and Transparent Audio cables for the woofers. The music is much crisper, cleaner, more detailed, deeper bass. I have no depth perception or image as the speaker placement to allow connecting directly to the amp is beyond horrible. Left channel is directly in front of me and the right channel is about 4 feet to the right of that.
Music directly from my amp the Bryston Mini-Ts sounds incredible, however due to the location of my audio gear and the lay out of the room, there is no way to get a good speaker placement using my current cables. Remodeling is out of the question, unless I tear out our fireplace, hearth, and mantle, the wife won't let that happen.
In order, to get direct wiring for the proper speaker placement that I have laid out, my left channel speaker is approximately 22 feet away from the amp and the right channel is 8 feet.
What would be the best solution to have the sound being direct wired to the amp with the Mini-Ts?
Should I buy 2-22 foot bi-wire cables to allow bi-amping, yes there is a noticeable improvement with the bi-amping, or should I buy 4-22 foot cables?
The reason, I am suggesting the matching 22 foot cables is I can clearly hear a difference in my separate BJC cable runs one is roughly 22 feet long (in-wall) and the other is roughly 45 feet long (in wall also) so to keep the cable characteristics the same, I'm
assuming 
I will need the same length of speaker cables for both channels. If I'm wrong please let me know, I'm just guessing at this piece.
With all this said, being a very poor guy, and being spoiled now with hearing the clarity of the AQ and TA cables, what and how should I go about finding this quality of speaker cable in these lengths?
How do you all manage long speaker cable runs?