There are so many factors in designing and building a room that will not have problems. A good reference is Dr. Floyd Toole's book, "Sound Reproduction: Loudspeakers and Rooms". Third edition recently came out.
Hiring a good acoustician with a proven track record is a good idea. You're not building a recording studio or control room, but the principals of small room acoustics still apply.
You need to consider HVAC, power distribution, lighting, acoustic treatment, isolation from the rest of the house and outside the home (keep sound in the room and prevent outside sound from coming in).
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