Do no harm!
The 125mA fuse on the C2300 main PCB protects the high voltage power supply in case of a catastrophic tube failure. Without actually measuring the current flowing through it, or checking with the manufacturer, you'd be gambling against the designer that chose that fuse size to begin with. A smaller fuse will do no harm, so if you're feeling lucky, go for it. 
It will be interesting to see if you can hear a difference after replacing it.
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Main System:
Amati Futura Mains
Amati Homage VOX Center,
Proac Response 1sc Rears,
Three MC2301's for L,C,R
MC 602 for the rears
C 1100, MX 151, MCD 1100, MR 80
Nottingham Dais with Wave Mechanic
Sumiko Palo Santos Presentation
SurfacePro 3, RPi 4, ROON, WW Starlight Platinum USB, Schiit Yggdrasil, Benchmark DAC3 HGC
MX 151, OppO BDP-95, JVC RS-500 DILA projector, 106" diagonal Stewart Luxus Screenwall Deluxe with Studiotek 130 G3 material.
Lake House:
Ohm F, MC 275V, C2300, MR 77, Rega P3
OnDeck:
McIntosh MAC 4300v
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