Ahhh, if only there were a simple and universal answer to your question! It is very system specific and cable specific. Case in point, I started with MIT single run cables, switched to DH Labs biwire cables, and now have Tara Labs single run, which sound the best. Would Tara biwires sound better? I don't know, but I do know I can't afford that kind of experiment! The cable investment would be almost the same cost as my speakers. There should be plenty of guidance here for you from people with the same amps and speakers.
MC402, ARC LS26, Magnepan MG3.7R, PS Audio PWDII, ACI Force XL sub, Transparent, Wireworld, Tara